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The term entheogen proposes a radical inversion of customary attitudes towards religion as faith or as something concerned with an ultimate reality or truth that is not a construct: ‘en-theo-gen’ is less ‘enthused by an experience of God within’ than something akin to 'empowering our ability to imagine or create the divine.

Daniel Waterman
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Methods of detoxifying and processing plants for human use are known throughout the world, and include a variety of techniques, including dehydration, application of heat, leaching, and fermentation, among others (Johns and Kubo 1988). While it is difficult to trace the origins of these methods, or to answer the questions of how certain groups learned to detoxify and process useful plants in their environment, to make a blanket claim that certain cultures were incapable of discovering plant properties, and the methods necessary for rendering them same and useful, seems naive at best.

John Rush, Entheogens and the Development of Culture: The Anthropology and Neurobiology of Ecstatic Experience
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Several centuries ago it was believed that the fly agaric, combined with the bufotenin–containing mucus of toads, was an ingredient of witches' brews, which made flying on their broomsticks possible. Even Santa Claus and Father Christmas are connected to Fly Agaric and their reindeer, which, by the way, like their portion of fly agarics and 'living' water.

John Rush, Entheogens and the Development of Culture: The Anthropology and Neurobiology of Ecstatic Experience
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The growth patterns of mushrooms are difficult to view since they come and go so quickly, appearing and disappearing overnight as if by magic. Their apparent lack of seed is another feature that was likely observed by early peoples who encountered them, perhaps providing further mystery as to the origin of the strange organisms.

John Rush, Entheogens and the Development of Culture: The Anthropology and Neurobiology of Ecstatic Experience
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Due to their soft bodies and ephemeral nature, it is unlikely that biological evidence of mushrooms will even be discovered in the archaeological record. This fact poses certain difficulties in determining the antiquity of modern cultural uses of psychoactive mushrooms, like those in Mexico and Siberia, and makes it even more difficult to determine whether psychoactive mushrooms were recognized and used by historical culture groups that are now extinct.

John Rush, Entheogens and the Development of Culture: The Anthropology and Neurobiology of Ecstatic Experience
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The effect of hallucinogenic mushrooms on the user's experience and behavior depends in part on his or her personality and genetic predisposition, which can vary to a great extent from person to person. As symptoms of psychiatric disorders can sometimes be elicited after one-off use, people with a genetic tendency to depression or psychosis should be discouraged from using psychoactive mushrooms.

John Rush, Entheogens and the Development of Culture: The Anthropology and Neurobiology of Ecstatic Experience
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Toadstool mandarins are a form of toxic jellyfish whose tentacles are loaded with entheogenic venom. The effects of a mandarin sting are threefold. The first is a sharp stinging sensation; the second a nasty red welt, which may fester if not treated with a salve of toadstool mandarin doodoo. And the third is a bold of self-awareness, thanks to the entheogens in the venom. Having been stung, a victim's typical reaction will be something like:Owww. Zark, that hurts.Then:Oh no. Look at this nasty red welt. I'm in the swimsuit competition later.And finally:What? I'm a latent misogynist with father issues!If a person is allergic to mandarin venom, one sting will prompt total self-awareness, leading to either immediate catatonia or a career as a talk show pundit.

Eoin Colfer, And Another Thing...
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The recasting of the Origin Myth as a story about the perils of disobedience precipitated a kind of decoupling of scripture from religious experience: when religious authorities began to insist on the literal truth of scripture, they were effectively promoting a kind of secular rationalism that states that one does not need to have a religious experience of any kind to live a moral life: all one has to do is declare one’s faith in scripture, in the doctrine of Jesus’ divinity and such, and accept the authority of the Holy Catholic Church as God’s representative on Earth.

Daniel Waterman, Entheogens, Society and Law: The Politics of Consciousness, Autonomy and Responsibility
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As Ernest Becker observes in The Denial of Death, the very thought of disobeying authority appears to awaken the anxiety connected with the possible loss, during infancy, of parental love, respect or support. The unexamined beliefs and experiences that generate our reliance on, and deference to authority, seem rooted in a profound existential uncertainty: the patient looks to the doctor to relieve this uncertainty, not only about not feeling well and not knowing why, but also about not knowing what to do, what action to undertake. In other words, the expertise of the physician relieves the patient of some of the burden of responsibility.

Daniel Waterman, Entheogens, Society and Law: The Politics of Consciousness, Autonomy and Responsibility
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Systems of retributive justice work well as long as they are proportional. However, in complex societies, where the State is the arbiter of justice, proportionality may break down: offences created by the elite few become offences against the entire community.

Daniel Waterman, Entheogens, Society and Law: The Politics of Consciousness, Autonomy and Responsibility
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