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Individuals are not stable things, they are fleeting. Chromosomes too are shuffled into oblivion, like hands of cards soon after they are dealt. But the cards themselves survive the shuffling. The cards are the genes. The genes are not destroyed by crossing-over, they merely change partners and march on. Of course they march on. That is their business. They are the replicators and we are their survival machines. When we have served our purpose we are cast aside. But genes are denizens of geological time: genes are forever.

Richard Dawkins
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If the history of the last century taught us the dangers of empowering governments to determine genetic “fitness” (i.e., which person fits within the triangle, and who lives outside it), then the question that confronts our current era is what happens when this power devolves to the individual. It is a question that requires us to balance the desires of the individual— to carve out a life of happiness and achievement, without undue suffering— with the desires of a society that, in the short term, may be interested only in driving down the burden of disease and the expense of disability. And operating silently in the background is a third set of actors: our genes themselves, which reproduce and create new variants oblivious of our desires and compulsions— but, either directly or indirectly, acutely or obliquely, influence our desires and compulsions. Speaking at the Sorbonne in 1975, the cultural historian Michel Foucault once proposed that “a technology of abnormal individuals appears precisely when a regular network of knowledge and power has been established.” Foucault was thinking about a “regular network” of humans. But it could just as easily be a network of genes.

Siddhartha Mukherjee, The Gene: An Intimate History
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Different sorts of survival machine appear very varied on the outside and in their internal organs. An octopus is nothing like a mouse, and both are quite different from an oak tree. Yet in their fundamental chemistry they are rather uniform, and, in particular, the replicators that they bear, the genes, are basically the same kind of molecule in all of us—from bacteria to elephants. We are all survival machines for the same kind of replicator—molecules called DNA— but there are many different ways of making a living in the world, and the replicators have built a vast range of machines to exploit them. A monkey is a machine that preserves genes up trees, a fish is a machine that preserves genes in the water; there is even a small worm that preserves genes in German beer mats. DNA works in mysterious ways.

Richard Dawkins, The Selfish Gene
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The long-lived gene as an evolutionary unit is not any particular physical structure but the textual archival information that is copied on down the generations. [I]t is widely distributed in space among different individuals, and widely distributed in time over many generations. [A] successful gene will be one that does well in the environments provided by these other genes that it is likely to meet in lots of different bodies.

Richard Dawkins, The Blind Watchmaker: Why the Evidence of Evolution Reveals a Universe Without Design
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What shall it profit a male if he shall gain the whole world, and lose his immortal genes?

Richard Dawkins, The Selfish Gene
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Many people think that the theory of the selfish gene says that “animals try to spread their genes.” That misstates the facts and it misstates the theory. Animals, including most people, know nothing about genetics and care even less. People love their children not because they want to spread their genes (consciously or unconsciously) but because they can’t help it. That love makes them try to keep their children warm, fed, and safe. What is selfish is not the real motives of the person but the metaphorical motives of the genes that built the person. Genes “try” to spread themselves by wiring animals’ brains so the animals love their kin and try to keep warm, fed, and safe.

Steven Pinker, How the Mind Works
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Prediction in a complex world is a chancy business. Every decision that a survival machine takes is a gamble, and it is the business of genes to program brains in advance so that on average they take decisions that pay off. The currency used in the casino of evolution is survival, strictly gene survival, but for many purposes individual survival is a reasonable approximation.

Richard Dawkins, The Selfish Gene
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If we define "beauty" as having blue eyes (and only blue eyes), then we will, indeed, find a "gene for beauty." If we define "intelligence" as the performance on only one kind of test, then we will, indeed, find a "gene for intelligence." The genome is only a mirror for the breadth or narrowness of human imagination.

Siddhartha Mukherjee, The Gene: An Intimate History
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It’s not that I was categorically opposed to the idea of scientists and physicians using gene editing to introduce heritable changes into the human genome.

Jennifer A. Doudna, A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution
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What, after all, is so special about genes? The answer is that they are replicators. The laws of physics are supposed to be true all over the accessible universe. Are there any principles of biology which are likely to have similar universal validity? When astronauts voyage to distant planets and look for life, they can expect to find creatures too strange and unearthly for us to imagine. But is there anything which must be true of all life, wherever it is found, and whatever the basis of its chemistry? If forms of life exist whose chemistry is based on silicon rather than carbon, or ammonia rather than water, if creatures are discovered which boil to death at -100 degrees centigrade, if a form of life is found which is not based on chemistry at all, but on electronic reverberating circuits, will there still be any general principle which is true of all life? Obviously I do not know but, if I had to bet, I would put my money on one fundamental principle. This is the law that all life evolves by the differential survival of replicating entities. The gene, the DNA molecule, happens to be the replicating entity which prevails on our own planet. There may be others. If there are, provided certain conditions are met, they will almost inevitably tend to become the basis for an evolutionary process.

Richard Dawkins, The Selfish Gene
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