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“There's major depression, and then there's clinical depression. Major depression is what makes you jump off a bridge. I have clinical depression. I jump out of first story windows. It's the psychological equivalent of lying on a bed of rubber nails.”
Doug Westberg“ME/CFS is not synonymous with depression or other psychiatric ill- nesses. The belief by some that they are the same has caused much con- fusion in the past, and inappropriate treatment.Nonpsychotic depression (major depression and dysthymia), anxiety disorders and somatization disorders are not diagnostically exclusionary, but may cause significant symptom overlap. Careful attention to the timing and correlation of symptoms, and a search for those characteris- tics of the symptoms that help to differentiate between diagnoses may be informative, e.g., exercise will tend to ameliorate depression whereas excessive exercise tends to have an adverse effect on ME/CFS patients.”
Bruce M. Carruthers“If I had to define a major depression in a single sentence, I would describe it as a "genetic/neurochemical disorder requiring a strong environmental trigger whose characteristic manifestation is an inability to appreciate sunsets.”
Robert M. Sapolsky, Why Zebras Don't Get Ulcers“Mental health can be just as important as physical health - and major depression is one of the most commonly diagnosed mental illnesses.”
Michael Greger“On Major Depression, quoted by the great William Styron of Sophie's Choice & Darkness Visible:From Darkness Visible, William Styron"It is a positive and active anguish, a sort of psychical neuralgia, wholly unknown to normal life.”
William Styron“Most of you guys can't see the potential in a nervous breakdown. A real collapse. There's more chance of finding yourself in a major depression than there is in a bottle Prozac.”
Keith Ablow, Denial“In 2008, the national Coping with Cancer project published a study showing that terminally ill cancer patients who were put on a mechanical ventilator, given electrical defibrillation or chest compressions, or admitted, near death, to intensive care had a substantially worse quality of life in their last week than those who received no such interventions. And, six months after their death, their caregivers were three times as likely to suffer major depression. Spending one’s final days in an I.C.U. because of terminal illness is for most people a kind of failure. You lie on a ventilator, your every organ shutting down, your mind teetering on delirium and permanently beyond realizing that you will never leave this borrowed, fluorescent place. The end comes with no chance for you to have said goodbye or “It’s O.K.” or “I’m sorry” or “I love you.”People have concerns besides simply prolonging their lives. Surveys of patients with terminal illness find that their top priorities include, in addition to avoiding suffering, being with family, having the touch of others, being mentally aware, and not becoming a burden to others. Our system of technological medical care has utterly failed to meet these needs, and the cost of this failure is measured in far more than dollars. The hard question we face, then, is not how we can afford this system’s expense. It is how we can build a health-care system that will actually help dying patients achieve what’s most important to them at the end of their lives.”
Atul Gawande