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“Happiness and success require the highest possible optimism, with minimal expectations. Optimize without limits, and expect anything in particular.”
Ammar Moussa (عمار موسى)“Leaders are raised through training and experience. Nobody was born naturally with hand-gloves of leadership. We come to life to search for it, discover it and optimize it.”
Israelmore Ayivor, Leaders' Ladder“Dare to rise, when all voices behind you say you can’t get there, ignore them and move on… it’s not about the talents and gifts you have; it’s about how wise you optimize them!”
Israelmore Ayivor, Leaders' Watchwords“Discover a purpose that gives you passion. Develop a plan that makes you persistent. Design a preparation and motivates you to optimize your potentials. Do it because you love it!”
Israelmore Ayivor, Dream Big!: See Your Bigger Picture!“The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity of influenza HA. They probed in more detail the precise codons that are used by the virus to encode the influenza HA1 protein. The discriminated between codons on the basis of volatility. Each three-nucleotide codon is related by a single nucleotide change to nine 'mutational neighbours.' Of those nine mutations, some proportion change the codon to a synonymous codon and some change it to a nonsynonymous one, which directs the incorporation of a different amino acid into the protein. More volatile codons are those for which a larger proportion of those nine mutational neighbours encode an amino acid change. The use of particular codons in a gene at a frequency that is disproportionate to their random selection for encoding a chosen amino acid is termed codon bias. Such bias is common and is influenced by many factors, but here the collaborators found strong evidence for codon bias that was particular for and restricted to the amino acids making up the HA1 epitopes. Remarkably, they observed that influenza employs a disproportionate number of volatile codons in its epitope-coding sequences. There was a bias for the use of codons that had the fewest synonymous mutational neighbours. In other words, influenza HA1 appears to have optimized the speed with which it can change amino acids in its epitopes. Amino acid changes can arise from fewer mutational events. The antibody combining regions are optimized to use codons that have a greater likelihood to undergo nonsynonymous single nucleotide substitutions : they are optimized for rapid evolution.”
Michael G Cordingley, Viruses: Agents of Evolutionary Invention“Efforts are meant to optimize, not to waste. The right time to optimize it is when others are open to giving their buy-ins to participate.”
Ashish Patel“Societies would _not_ be better off if everyone were like Mr Spock, all rationality and no emotion. Instead, a balance - a teaming up of the internal rivals - is optimal for brains. ... Some balance of the emotional and rational systems is needed, and that balance may already be optimized by natural selection in human brains.”
David Eagleman, Incognito: The Secret Lives of the Brain“Don't settle for anything less. Rise up and optimize your talents through strategic thinking and big dream. Your God should be your guide in all things.”
Israelmore Ayivor, Michelangelo | Beethoven | Shakespeare: 15 Things Common to Great Achievers“When you optimize your talents very well, you can pick money from people's pockets and nobody will ever get the guts to call you a thief.”
Israelmore Ayivor