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Random mutations much more easily debilitate genes than improve them, and that this is true even of the helpful mutations. Let me emphasize, our experience with malaria’s effects on humans (arguably our most highly studied genetic system) shows that most helpful mutations degrade genes. What’s more, as a group the mutations are incoherent, meaning that they are not adding up to some new system. They are just small changes - mostly degradative - in pre-existing, unrelated genes. The take-home lesson is that this is certainly not the kind of process we would expect to build the astonishingly elegant machinery of the cell. If random mutation plus selective pressure substantially trashes the human genome, why should we think that it would be a constructive force in the long term? There is no reason to think so.

Michael J. Behe
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Natural selection eliminates and maybe maintains, but it doesn't create... Neo-Darwinists say that new species emerge when mutations occur and modify an organism. I was taught over and over again that the accumulation of random mutations led to evolutionary change [which] led to new species. I believed it until I looked for evidence.

Lynn Margulis
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I was taught over and over again that the accumulation of random mutations led to evolutionary change - led to new species. I believed it until I looked for evidence.

Lynn Margulis
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The Kalam Cosmological Argument, The Fine-Tuning Argument, and The Local Fine-Tuning Argument all do an end-run around the issue of special creation verses evolution. These evidences establish the existence of a Creator of the universe. Thanks to The Kalam Cosmological Argument and the two Fine-Tuning Arguments, the atheist’s goose is cooked before we even get to the issue of the origin of life much less the adequacy of random mutations and natural selection to produce new species of animals! .... I can give the atheist evolution for free. He still has to deal with all of the arguments in this book.

Evan Minton, Inference To The One True God: Why I Believe In Jesus Instead Of Other Gods
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There are many examples where species share common plastic traits. What appears to be convergence may just be the plastic response of the organism to its environment. Examples include the following: Limbs that protrude from an animal’s body have more surface area per unit mass than the rest of the body. In cold weather the animal loses more heat per unit mass from these limbs than from other parts of the body. In many species the tails and legs are shorter for those living in colder climates and larger for those in warmer climates. Gulls’ wings are shorter in cold climates than in warm. Hares and foxes also have shorter ears in cold climates than in warm. Eskimos have shorter arms and legs than do people living in warmer climates. . . . Jodan’s rule: Many species of fish tend to have more vertebrae when they live in cold water than do the same species living in warm water. These differences have been shown to depend on the temperature at which the fish have been reared.

What these rules show is not convergence. They show that different species adopt the same anatomical strategies when they have to cope with the same environmental conditions. We have seen that these strategies cannot come from random mutations. It is much more reasonable to say they come from environmental cues acting on the genetic program.
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