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“The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity of influenza HA. They probed in more detail the precise codons that are used by the virus to encode the influenza HA1 protein. The discriminated between codons on the basis of volatility. Each three-nucleotide codon is related by a single nucleotide change to nine 'mutational neighbours.' Of those nine mutations, some proportion change the codon to a synonymous codon and some change it to a nonsynonymous one, which directs the incorporation of a different amino acid into the protein. More volatile codons are those for which a larger proportion of those nine mutational neighbours encode an amino acid change. The use of particular codons in a gene at a frequency that is disproportionate to their random selection for encoding a chosen amino acid is termed codon bias. Such bias is common and is influenced by many factors, but here the collaborators found strong evidence for codon bias that was particular for and restricted to the amino acids making up the HA1 epitopes. Remarkably, they observed that influenza employs a disproportionate number of volatile codons in its epitope-coding sequences. There was a bias for the use of codons that had the fewest synonymous mutational neighbours. In other words, influenza HA1 appears to have optimized the speed with which it can change amino acids in its epitopes. Amino acid changes can arise from fewer mutational events. The antibody combining regions are optimized to use codons that have a greater likelihood to undergo nonsynonymous single nucleotide substitutions : they are optimized for rapid evolution.”
Michael G Cordingley
“When you feel annoyed, when you feel pain, that's when you have the opportunity to meet and confront yourself. It is when we are most emotionally volatile that we expose our true selves. Unresolved pain, frustration and grievance come to the surface. We can let this torment and torture us, pulling us to and fro, or we can use these moments to come face to face with ourselves. Why do we feel the way we do? Why do we feel compelled to act in a certain matter. Is this serving us? Are we serving our own best interest? Is there something we could do to help ourselves? Are we exercising compassion to ourselves and others? Don't be afraid to confront or question yourself. Remember to be extra loving, patient, forgiving and kind to yourself when you are emotionally volatile. Move gently forward in cooperation with yourself.”
Akiroq Brost“Fear tends to manifest itself much more quickly than greed, so volatile markets tend to be on the downside. In up markets, volatility tends to gradually decline.”
Philip Roth“I could do with a bit more excess. From now on I'm going to be immoderate--and volatile--I shall enjoy loud music and lurid poetry. I shall be rampant.”
Joanne Harris, Chocolat“Definitions and meanings change all the time. Truth and reality are very volatile, indefinite, multi layered and sometimes very paradoxical. That’s why it is very fiddly to make a set definition for the phenomena of our daily life. ( " Did not expect it would ever happen, there" )”
Erik Pevernagie“Coincidence sometimes volatile”
other times a slow spark that rekindles our destiny's light“As love without esteem is capricious and volatile”
esteem without love is languid and cold.“And these are the sametype of people who killthe innocent andjustify it by saying“They’ve gone to bewith Jesus now”But we won’t talkabout how theycrucified Him, too”
Phil Volatile“Finch was his own country, the government unstable, the population volatile.”
Kealan Patrick Burke, KINAll in One Creative & Marketing Platform to tell stories at scale
