History repeats, but science reverberates.

History repeats, but science reverberates.

Siddhartha Mukherjee
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My memory of my household is of one immersed in books and music. I have a very intimate relationship with Bengali literature, particularly Tagore, and my interest besides reading then was music.

Siddhartha Mukherjee
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Cell culture is a little like gardening. You sit and you look at cells, and then you see something and say, 'You know, that doesn't look right'.

Siddhartha Mukherjee
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There is an enormous amount of options that a physician can provide today, right down from curing patients, treating patients, or providing patients with psychic solace or pain relief. So, in fact, the gamut of medical intervention is enormous.

Siddhartha Mukherjee
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A strong intuition is much more powerful than a weal test. Normals teach us rules; outliers teach us laws. For every perfect medical experiment, there is a perfect human bias.

Siddhartha Mukherjee
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In a spiritual sense, a positive attitude may help you get through chemotherapy and surgery and radiation and what have you. But a positive mental attitude does not cure cancer - any more than a negative mental attitude causes cancer.

Siddhartha Mukherjee
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It is hard to look at the tumor and not come away with the feeling that one has encountered a powerful monster in its infancy

Siddhartha Mukherjee
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In our adventures, we have only seen our monsters more clearly and described his scales and fangs in new ways - ways that reveal a cancer cell to be. like Grendel, a distorted version of ourselves." -1989 Nobel Prize Speech, Cited in Siddhartha Mukherjee's Emperor of All Maladies

Harold Varmus
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Scientists divide. We discriminate. It is the inevitable occupational hazard of our profession that we must break the world into its constituent parts -- genes, atoms, bytes -- before making it whole again. We know of no other mechanism to understand the world: to create the sum of its parts, we must begin by dividing it into the parts of the sum.

Siddhartha Mukherjee, The Gene: An Intimate History
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If the history of the last century taught us the dangers of empowering governments to determine genetic “fitness” (i.e., which person fits within the triangle, and who lives outside it), then the question that confronts our current era is what happens when this power devolves to the individual. It is a question that requires us to balance the desires of the individual— to carve out a life of happiness and achievement, without undue suffering— with the desires of a society that, in the short term, may be interested only in driving down the burden of disease and the expense of disability. And operating silently in the background is a third set of actors: our genes themselves, which reproduce and create new variants oblivious of our desires and compulsions— but, either directly or indirectly, acutely or obliquely, influence our desires and compulsions. Speaking at the Sorbonne in 1975, the cultural historian Michel Foucault once proposed that “a technology of abnormal individuals appears precisely when a regular network of knowledge and power has been established.” Foucault was thinking about a “regular network” of humans. But it could just as easily be a network of genes.

Siddhartha Mukherjee, The Gene: An Intimate History
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History repeats itself, in part because the genome repeats itself. And the genome repeats itself, in part because history does. The impulses, ambitions, fantasies, and desires that drive human history are, at least in part, encoded in the human genome. And human history has, in turn, selected genomes that carry these impulses, ambitions, fantasies, and desires. This self-fulfilling circle of logic is responsible for some of the most magnificent and evocative qualities in our species, but also some of the most reprehensible. It is far too much to ask ourselves to escape the orbit of this logic, but recognizing its inherent circularity, and being skeptical of its overreach, might protect the week from the will of the strong, and the 'mutant' from being annihilated by the 'normal'.

Siddhartha Mukherjee, The Gene: An Intimate History
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