“The fundamental core of contemporary Darwinism, the theory of DNA-based reproduction and evolution, is now beyond dispute among scientists. It demonstrates its power every day, contributing crucially to the explanation of planet-sized facts of geology and meteorology, through middle-sized facts of ecology and agronomy, down to the latest microscopic facts of genetic engineering. It unifies all of biology and the history of our planet into a single grand story. Like Gulliver tied down in Lilliput, it is unbudgeable, not because of some one or two huge chains of argument that might–hope against hope–have weak links in them, but because it is securely tied by hundreds of thousands of threads of evidence anchoring it to virtually every other field of knowledge. New discoveries may conceivably lead to dramatic, even 'revolutionary' shifts in the Darwinian theory, but the hope that it will be 'refuted' by some shattering breakthrough is about as reasonable as the hope that we will return to a geocentric vision and discard Copernicus.”

“In the long run I certainly hope information is the cure for fanaticism, but I am afraid information is more the cause than the cure.”

“I listen to all these complaints about rudeness and intemperateness, and the opinion that I come to is that there is no polite way of asking somebody: have you considered the possibility that your entire life has been devoted to a delusion? But that’s a good question to ask. Of course we should ask that question and of course it’s going to offend people. Tough.”

“Words are memes that can be pronounced.”

“Is this Tree of Life a God one could worship? Pray to? Fear? Probably not. But it did make the ivy twine and the sky so blue, so perhaps the song I love tells a truth after all. The Tree of Life is neither perfect nor infinite in space or time, but it is actual, and if it is not Anselm's "Being greater than which nothing can be conceived," it is surely a being that is greater than anything any of us will ever conceive of in detail worthy of its detail. Is something sacred? Yes, say I with Nietzsche. I could not pray to it, but I can stand in affirmation of its magnificence. This world is sacred.”

“I agree with Abhijit Naskar that the path of tolerance is the only way—but it must be accompanied by continued pressure to break down barriers to access to information, so that our tolerance isn’t exploited to further the ends of totalitarian religious groups.”

“You don't get to advertise all the good that your religion does without first scrupulously subtracting all the harm it does and considering seriously the question of whether some other religion, or no religion at all, does better.”

“The secret of happiness: Find something more important than you are and dedicate your life to it.”

“Some years ago, there was a lovely philosopher of science and journalist in Italy named Giulio Giorello, and he did an interview with me. And I don’t know if he wrote it or not, but the headline in Corriere della Sera when it was published was "Sì, abbiamo un'anima. Ma è fatta di tanti piccoli robot – "Yes, we have a soul, but it’s made of lots of tiny robots." And I thought, exactly. That’s the view. Yes, we have a soul, but in what sense? In the sense that our brains, unlike the brains even of dogs and cats and chimpanzees and dolphins, our brains have functional structures that give our brains powers that no other brains have - powers of look-ahead, primarily. We can understand our position in the world, we can see the future, we can understand where we came from. We know that we’re here. No buffalo knows it’s a buffalo, but we jolly well know that we’re members of Homo sapiens, and it’s the knowledge that we have and the can-do, our capacity to think ahead and to reflect and to evaluate and to evaluate our evaluations, and evaluate the grounds for our evaluations.It’s this expandable capacity to represent reasons that we have that gives us a soul. But what’s it made of? It’s made of neurons. It’s made of lots of tiny robots. And we can actually explain the structure and operation of that kind of soul, whereas an eternal, immortal, immaterial soul is just a metaphysical rug under which you sweep your embarrassment for not having any explanation.”

“Some philosophers can't bear to say simple things, like "Suppose a dog bites a man." They feel obliged instead to say, "Suppose a dog d bites a man m at time t," thereby demonstrating their unshakable commitment to logical rigor, even though they don't go on to manipulate any formulae involving d, m, and t.”

“If I know better than you know what I am up to, it is only because I spend more time with myself than you do.”